SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage

2021

Abstract

Autoimmune diseases (ADs) could occur due to infectious diseases and vaccination programs. Since millions of people are expected to be infected with SARS-CoV-2 and vaccinated against it, autoimmune consequences seem inevitable. Therefore, we have investigated the whole proteome of the SARS-CoV-2 for its ability to trigger ADs. In this regard, the entire proteome of the SARS-CoV-2 was chopped into more than 48000 peptides. The produced peptides were searched against the entire human proteome to find shared peptides with similar experimentally confirmed T-cell and B-cell epitopes. The obtained peptides were checked for their ability to bind to HLA molecules. The possible population coverage was calculated for the most potent peptides. The obtained results indicated that the SARS-CoV-2 and human proteomes share 23 peptides originated from ORF1ab polyprotein, nonstructural protein NS7a, Surface glycoprotein, and Envelope protein of SARS-CoV-2. Among these peptides, 21 peptides had experimentally confirmed equivalent epitopes. Amongst, only nine peptides were predicted to bind to HLAs with known global allele frequency data, and three peptides were able to bind to experimentally confirmed HLAs of equivalent epitopes. Given the HLAs which have already been reported to be associated with ADs, the ESGLKTIL, RYPANSIV, NVAITRAK, and RRARSVAS were determined to be the most harmful peptides of the SARS-CoV-2 proteome. It would be expected that the COVID-19 pandemic and the vaccination against this pathogen could significantly increase the ADs incidences, especially in populations harboring HLA-B*08:01, HLA-A*024:02, HLA-A*11:01 and HLA-B*27:05. The Southeast Asia, East Asia, and Oceania are at higher risk of AD development.

https://pubmed.ncbi.nlm.nih.gov/34447375/

Listen Up, Mr. Gates: Vaccinating into a Pandemic Is ALWAYS the Wrong Answer

June 5, 2022

Dr. Mike Yeadon: “The elapsed time taken to get an adequate amount of safety data is always longer than the feasible length of any pandemic in history. In other words, a new vaccine is always, let me say it again, always, Mr. Gates, the wrong answer. It will always take you longer to do a responsible job of creating and testing a novel vaccine than the length of the pandemic. And if you take less time, it means you do not have an appropriate amount of safety data and therefore it’s reckless to go and vaccinate the whole population.”

Early combination therapy with hydroxychloroquine and azithromycin reduces mortality in 10,429 COVID-19 outpatients

March 10, 2022

Published in Reviews on Cardiovascular Medicine

Treatment with HCQ+AZ (0.17 [0.06–0.48]) was associated with a lower risk of death, independently of age, sex and epidemic period. Meta-analysis evidenced consistency with 4 previous outpatient studies (32,124 patients—Odds ratio 0.31 [0.20–0.47], I22 = 0%). Early ambulatory treatment of COVID-19 with HCQ+AZ as a standard of care is associated with very low mortality, and HCQ+AZ improve COVID-19 survival compared to other regimens.

https://www.imrpress.com/journal/RCM/22/3/10.31083/j.rcm2203116

1,287,595 Injuries Reported After COVID Shots, Vaccine Injury Compensation Programs ‘Overwhelmed’

June 3, 2022

VAERS data released Friday by the Centers for Disease Control and Prevention show 1,287,595 reports of adverse events from all age groups following COVID-19 vaccines, including 28,532 deaths and 235,041 serious injuries between Dec. 14, 2020, and May 27, 2022.

https://childrenshealthdefense.org/defender/injuries-covid-shots-vaccine-vaers/?utm_source=salsa&eType=EmailBlastContent&eId=04a3c2d7-c720-450d-bd59-6518192bbe88

TWO New Studies Show POSSIBLE Link Between Degenerative Brain Disease and the Experimental Covid-19 Vaccine

June 5, 2022, by J Conradson

Two new clinical studies – one peer-reviewed by researchers in Turkey, and one pre-print by researchers in France – have begun to establish an alarming link between an incurable, degenerative brain disease called Creutzfeldt-Jakob disease (CJD) and the experimental Covid-19 vaccine.

CJD is a “rare” disease that is caused by abnormal infectious proteins in the brain called “prions,” according to NHS. Although the presence of prions is not necessarily dangerous or deadly, the proteins will cause degenerative brain damage if they become diseased or misfolded. Once this process begins, the malfunctioning prions will continue to corrupt other cells, leading to a prognosis that is always fatal.

As of right now, CJD is uncurable. There are zero treatment options available. The diagnosis is essentially a death sentence, but symptoms are traditionally dormant for several years before manifesting into a deadly complication.

Unfortunately, with the new cases of CJD that have been linked to the vaccine, that doesn’t seem to be the case. The disease is progressing at an alarming and unprecedented rate. So much so that the team of French researchers highlighted their concerns of the experimental mRNA vaccines contributing directly to creating a new, more aggressive type of CJD.

According to the French study, a total of 26 cases of vaccine-linked CJD were included in the research.

At the time of the study’s publication, a whopping 20 out of the 26 CJD patients had already passed away from the disease. Additionally, researchers found that there were “more than 50 cases” of the fatal disease that appeared after taking the experimental vaccines.

Despite traditionally taking as much as a decade to manifest with symptoms, the study found symptoms in these new cases began appearing just 11.38 days post-vaccination. In these cases, the disease is killing the affected individuals in under 5 months’ time (4.76 months).

From the French pre-print:

“…we are analyzing the concomitance of cases, which occurred in various European countries, between the first doses of Pfizer or Moderna mRNA vaccine and the sudden and rapid onset of the first symptoms of Creutzfeldt-Jakob disease, which usually requires several years before observing its first symptoms…

Full Episode #32: Health Freedom

June 3, 2022

At time 0:00 – Covid News Update

At time13:35 – Bob Snow was a USAF pilot, instructor and evaluator from 1983-1990. From 1991 to the present he has been an airline pilot, instructor and evaluator. He has extensive domestic and international flight experience in both military and civilian. Bob has over 22,000 accident free flight hours. Unfortunately he suffered a severe vaccine injury and went into cardiac arrest six minutes after landing a plane.

At time 38:48 – Dr. Merritt is a former Navy Surgeon, and has been in the private practice of Orthopedic and Spinal Surgery since 1995, she has served on the Board of the Arizona Medical Association, and is past president of the Association of American Physicians and Surgeons. Dr. Merritt was featured in the Time Is Now documentary.

https://odysee.com/@VSRF:d/VSRFWeeklyUpdateEP32_060222:1