July 8, 2022
Interesting how physical activity & nutrition have a very powerful affect on Covid outcomes:
[…] Before the virus can infect a cell, its Spike proteins must undergo processing steps, such as palmitic acid attachment, also known as palmitoylation. Nitric oxide in the blood vessels inhibits the palmitoylation of Spike proteins. If you have higher nitric oxide levels in your blood vessels, the virus will not be able to replicate nearly as quickly. Nitric oxide is antiviral against SARS. So, if you have a condition, like pre-existing endothelial dysfunction from being obese, hypertensive, diabetic, old, and/or [adult] African-American, youâre going to be way, way more vulnerable to this virus, and this is what we see in the real world. COVID-19 cannot readily cause outbreaks in places where people have pescetarian endothelial support diets, like much of Southeast Asia and Japan, nor can it do so in countries with a low average age, like Africa, where people have the âbenefitâ of being young enough on average that they donât have endothelial dysfunction, simply due to the poor life expectancy of these countries.
Endothelial dysfunction is everything, when it comes to COVID-19. If you can raise your nitric oxide levels and improve your endothelial health by engaging in chronic exercise, increasing your intake of dietary nitrate, Vitamin D, and antioxidant substrates like cysteine and selenium, you should do it. There is no magic pill for endothelial health. The cure for endothelial dysfunction is called daily jogging. So, what did the authorities do for COVID-19? They locked people down inside their homes, with no sunlight, and they encouraged sedentary behavior, which makes your vascular endothelium unhealthy, which, in the aggregate, makes people more vulnerable to COVID-19.
[…] Nitric oxide is whatâs called a gasotransmitter. Itâs a very small molecule that can rapidly diffuse through normally impermeable cell membranes and acts as a signal to cells to alter their behavior. Nitric oxide has tons of different functions in the body and even functions as a neurotransmitter, but one of the things it does is dilate blood vessels and lower blood pressure. You can see the effects for yourself in about two seconds by engaging in nose breathing, which greatly increases your nitric oxide levels and lowers your blood pressure, producing a noticeable calming effect. Dietary nitrate consumption in nitrate-rich foods like beets and leafy greens also increases your nitric oxide levels by the enterosalivary nitrate pathway. Nitric oxide cannot be stockpiled by the human body, because itâs a tiny, reactive gaseous molecule with a very, very short half-life of just a few seconds. Nitric oxide has to be produced and consumed constantly by nitric oxide synthase in your blood vessels.
https://iceni.substack.com/p/spartacast-02?utm_source=substack&utm_medium=email#details