McCullough Spike Detox

Sept 2026

The current McCullough Protocol for addressing persistent spike proteins (from viral infections or vaccination) is known as the [Base Spike Detoxification (BSD) protocol] (https://pmc.ncbi.nlm.nih.gov/articles/PMC10663976/#:~:text=The%20protocol%20includes%20a,mechanisms%20of%20action%3A). [1, 2]

## Base Spike Detoxification (BSD) Regimen
The core oral triple-agent regimen proposed by Dr. Peter McCullough and colleagues consists of: [1, 3]

* Nattokinase: 2,000 FU (approx. 100 mg) orally twice daily on an empty stomach. (Aims to degrade spike protein and reduce clotting risks).

* Bromelain: 500 mg orally once daily on an empty stomach. (Aims to help break down proteins and support fibrinolysis).

* Curcumin: 500 mg orally twice daily. Nano, liposomal, or piperine-enhanced formulations are preferred for better absorption to help lower tissue inflammation. [3, 4, 5]

Key Mechanisms

* Proteolytic Cleavage: Nattokinase and bromelain target the breakdown of the spike protein structure.

* Anti-inflammatory: Curcumin helps suppress inflammatory pathways (such as NF-kB) triggered by spike fragments.

* Vascular Support: Helps with the dissolution of microthrombi and provides anticoagulant support. [1, 5]

Note: Medical mainstream organizations note that large-scale, randomized controlled trials for spike detoxification protocols remain limited, and patients taking concurrent blood thinners or antiplatelet drugs must exercise caution with nattokinase. [4, 6]

[1] [https://pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC10663976/)
[2] [https://www.researchgate.net](https://www.researchgate.net/figure/McCullough-Protocol-Base-Spike-Detoxification-BSD-A-Dissolution-of-spike_fig2_375814234)
[3] [https://www.ifmsynergy.com](https://www.ifmsynergy.com/the-mccullough-protocol-for-long-covid-what-the-evidence-actually-shows/)
[4] [https://www.biospace.com](https://www.biospace.com/potential-covid-spike-protein-detoxification-regime-discussed-in-journal-of-american-physicians-and-surgeons-aaps)
[5] [https://www.researchgate.net](https://www.researchgate.net/figure/McCullough-Protocol-Base-Spike-Detoxification-BSD-A-Dissolution-of-spike_fig2_383114457)
[6] [https://pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38024037/)

The War They Declared On Their Own People

Sept 21, 2026

Thesis of the interview: The pandemic was not managed — it was weaponized. A wartime legal architecture turned a respiratory virus into a compliance event, and every institution that should have treated patients instead funneled them toward a single product.

https://open.substack.com/pub/petermcculloughmd/p/the-war-they-declared-on-their-own?utm_source=share&utm_medium=android&r=o554c

The Holy Trinity – diet, fitness, sleep

PETER A. MCCULLOUGH, MD, MPH
Sept 17, 2026

The Holy Trinity – diet, fitness,
sleep – and why the best
anxiety remedy is a hard
workout. Dr McCullough with
Emmy Award Winner Kerstin
Lindquist

The Pandemic Retrospective

Dr. McCullough frames the era as an “awakening”,

* He asserts the virus was lab-engineered in Wuhan and that the spike protein persists in the body, causing long COVID clots, heart damage, and autoimmunity.

* He claims the mRNA vaccines deliver ~10x the spike protein load of natural infection, citing a Barham et al. paper, and calls for their removal from market.

* He praises Novavax as the safest option and notes only ~9% of Americans still take boosters.

* His preferred approach: early treatment – nasal sprays, gargling, the “McCullough Protocol,” monoclonal antibodies, and oral ivermectin as the “superstar” drug

* He discusses Anthony Fauci’s diary, alleging Fauci developed a post-vaccine blood clot but concealed it, and that Fauci sought clemency from Biden.

Daily Health Non-Negotiables

McCullough outlines his own routine:

* Nasal spray + gargle twice daily (saltwater, iodine, or xylitol-based products like Immune Defense, Xlear/Spry) to disrupt viral replication.

* “Ultimate Spike Detox” — nattokinase, bromelain, and curcumin to dissolve spike protein, plus sweating (sauna) as an elimination pathway.

* His Diet (the “Holy Trinity”): diet, fitness, sleep. He prioritizes fish, beans, nuts, egg whites, nonfat dairy; lean chicken and beef, avoids pork (citing genetic vaccines in pork), and cuts the “three S’s” — sugars/sweets, starches, and saturated fat.

* Alcohol: urges a 90-day alcohol-free challenge, noting even one drink can disrupt sleep architecture for months.

* Sleep: older adults need less sleep (7–8 hours), and physical activity is his top anxiety/stress/sleep remedy.

* He plugs Vesper (a nootropic non-alcoholic cocktail) and improved non-alcoholic beers for social events.

Where to Find Him

Dr. Peter A. McCullough, MD, MPH, appointments www.peteramcculloughmd.com

Chief Scientific Officer, The Wellness Company www.twc.health/focalpoints

President, McCullough Foundation, www.mcculloughfnd.org

Author, Courage to Face COVID-19: Preventing Hospitalization and Death While Battling the Bio-Pharmaceutical Complex and NYT Best Seller Vaccines: Mythology, Ideology, and Reality

https://open.substack.com/pub/petermcculloughmd/p/want-a-good-nights-sleep-and-better?utm_source=share&utm_medium=android&r=o554c

The Pfizer Papers

Sept 10, 2026

“The Pfizer Papers” is a book by Naomi Wolf that critically examines Pfizer’s COVID-19 vaccine development, clinical trials, and safety data. The book is based on primary source Pfizer clinical trial documents that were released under court order, along with related medical literature. Naomi Wolf synthesizes these findings into a comprehensive critique, highlighting alleged issues and concerns about the vaccine’s development and approval process.

Naomi Wolf is an established author with a background in English Literature from Oxford and has written several nonfiction bestsellers on women’s issues and civil liberties. In “The Pfizer Papers,” she focuses on what she describes as crimes against humanity related to Pfizer’s vaccine trials.

*******

Why so little follow-up research?

In the context of “The Pfizer Papers” by Naomi Wolf the reason for lack of public discussion, media coverage, or scientific follow-up on certain findings or concerns raised about Pfizer’s COVID-19 vaccine trials is complex.

Here is a detailed analysis of possible reasons for this silence and limited follow-up research:

1. Complexity and Accessibility of Data

The Pfizer clinical trial documents are extensive, technical, and complex, making it difficult for the general public and even many researchers to fully analyze without specialized expertise.
This complexity can lead to slower dissemination and understanding of the findings, contributing to less immediate follow-up.

2. Regulatory and Institutional Barriers

Regulatory agencies like the FDA and EMA have their own review processes and may be cautious about reopening or revisiting approved vaccine data without strong new evidence.
Institutional inertia and reliance on initial approvals can reduce incentives for further independent research or public re-examination.

3. Media and Public Narrative Control

Mainstream media often rely on official sources and expert consensus, which have broadly supported the safety and efficacy of COVID-19 vaccines.
Controversial or critical findings may be downplayed or ignored to avoid public panic or misinformation, especially during a global health crisis.

4. Scientific and Political Polarization

COVID-19 vaccines have become highly politicized, and research that challenges the dominant narrative can face resistance or dismissal.
Researchers may be reluctant to pursue follow-up studies that could be perceived as politically motivated or controversial.

5. Funding and Research Priorities

Research funding is often directed by government agencies, pharmaceutical companies, or institutions with vested interests.
Studies that might question vaccine safety or efficacy may struggle to secure funding or publication opportunities.

6. Ethical and Legal Constraints

Patient confidentiality, trial participant anonymity, and legal restrictions can limit access to detailed data for independent researchers.
Legal battles over data transparency can delay or restrict follow-up investigations.

7. Scientific Consensus and Risk-Benefit Analysis

The prevailing scientific consensus appears to support the benefits of COVID-19 vaccines in preventing severe disease and death. This consensus may lead to deemphasizing or deprioritizing research into adverse effects that are considered rare or outweighed by benefits.

Summary

The silence and limited follow-up research on certain subjects raised in “The Pfizer Papers” can be attributed to a combination of technical complexity, regulatory caution, media dynamics, political polarization, funding challenges, legal constraints, and prevailing scientific consensus. These factors together create an environment where critical or controversial findings may not receive the attention or investigation some expect.

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Personal Comment from your editor: During the pandemic, when asked for specific data regarding vaccine research groups, my employer’s corporate medical advisor made it clear that the employees themselves were the actual research subjects, stating: “WE are the cohorts of this study.”

We deserve follow-up research.

Mankind’s History w/ Vaccines

Aug 29, 2026

By Peter A. McCullough, MD, MPH

Please enjoy this long format state presentation given on August 21 at the Advent Mission Institute Camp 365 in Berrien Springs, Michigan. I reconnected with church leaders who suffered severe professional reprisal for their presentation to congregations of the “crisis of conscience” we all faced with mandated genetic vaccines for COVID-19 in 2021.

https://substack.com/@petermcculloughmd/note/p-212980872?r=o554c

Dr McCullough Carpeting w/ Truth Bombs

By Peter A. McCullough, MD, MPH

Aug 23, 2026

https://substack.com/@petermcculloughmd/note/p-211861323?r=o554c

Dr. Peter McCullough is an internist, cardiologist, and epidemiologist with degrees from Baylor University, University of
Texas Southwestern Medical School, University of Michigan, and Southern Methodist University. With over 1,000
publications and more than 700 citations in the National Library of Medicine, Dr. McCullough has established himself as a
prominent voice in medicine and public health policy.

In this conversation, Dr. McCullough discusses his views on COVID-19 treatment, protocols, vaccine safety concerns, and the intersection of medicine and public health policy. He shares insights from his experience testifying before the US Senate, US House of Representatives, European Parliament, and
state legislatures on matters of public health.