Abdominal pressure syndrome = lack of dietary fiber leading to chronic constipation; leading to straining at defecation with Valsalva maneuver; leading to chronic increased abdominal pressure; leading to hemorrhoids, diverticulosis, diverticlulitis, varicose veins, hernias, varicocele, hiatal hernia, GERD, esophageal cancer. Dry stool also associated with appendicitis. Slow stool transit time, high fat diet, lack of fiber are associated with increased risk of colon cancer, and lack of fiber with increased risk of leaky gut. Leaky gut is associated with autoimmune disease.